Lectures/Presentations:
Heart Failure in Rats Causes Changes in Skeletal Muscle Which Are Not Explained by Reduced Activity. Astra-Merck Young Investigator Symposium, San Francisco. September, 1995
Macrophage-Derived Angiogenic Factor IL-8, CXC, and CC Chemokines Are Expressed
in Acute Coronary Syndromes. Council on Atherosclerosis, Scientific Sessions American Heart Association, New Orleans. November, 1996
IL-8 Mediated Angiogenesis in Human Coronary Atheroma. Astra-Merck Young Investigator Symposium, Washington, DC.September, 1997
IL-8 Is a Major Angiogenic Factor in Atherosclerosis . Michigan American College of Cardiology Symposium, Shanty Creek, MI. October,1997
IL-8 Is a Major Angiogenic Factor in Human Atherectomy Tissue . Council on Atherosclerosis, Scientific Sessions American Heart Association, Orlando. November, 1997
IL-8 Mediates Angiogenesis in Coronary Atherosclerosis International Symposium on Coronary Thrombosis and Atherosclerosis, Gavleston,TX. December, 1997
Molecular Mechanisms Behind the Neurohormonal Hypothesis. Cardiology Grand Rounds Cedars Sinai Medical Center, Los Angeles, CA. June 1998
Chemokines in Atherosclerosis. Cardiology Grand Rounds University of Michigan, Ann Arbor, MI. August 1998
Advanced Heart Failure Treatment. Community Lecture, Los Angeles, CA. September 1998
The Role of CXC Chemokines in Atherosclerosis World Congress on Cardiology, Florence, Italy. October 1998
Expression of ELR-CXC Chemokines Are Associated with Allograft Atherosclerosis after Human Cardiac Transplantation and in the Rat Model. Scientific Sessions, American Heart Association. Dallas, November 1998
Management of Outpatient Heart Failure Merck Physicians, Seattle, WA. December 1998
Therapies in Advanced Heart Failure: Left Ventricular Assist Devices. Cardiology Grand Rounds Cedars Sinai Medical Center, Los Angeles, CA. December 1998
CHF Treatments in the 21st Century. American College of Physicians/American Society of Internal Medicine, Southern California Chapter, Los Angeles, CA. February 1999.
Angiotensin II Receptor Blockade Antagonizes the Proliferative Effects of Oxidized LDL on Coronary Smooth Muscle Cells Via Inhibition of Angiogenic Chemokines. American College of Cardiology, New Orleans, LA. March 1999
5 Million Failing Hearts: Reaching Patients, Reaching Goals, Faculty for ACCEL Healthcare CME Program, University of Cincinnati. Santa Monica, CA May 1999
Current Advances in Cardiology, “Current Management in Heart Failure” Heart Institute of the High Desert, Apple Valley, CA May 1999
Cytokine Activation in Heart Failure;“The Inflammatory Hypothesis” Cardiology Grand Rounds UCLA Medical Center, Los Angeles, CA. June 1999
Inflammatory Angiogenic Chemokines Are Associated with iNOS Expression in Failing Human Hearts, American Heart Association: Scientific Conference on Molecular, Cellular, and Integrated Physiological Approaches to the Failing Heart, Snowbird Conference Center, Utah. August 1999
Living with Heart Failure , Los Angeles Times Annual Festival of Health, University of Southern California, Los Angeles, CA. October 1999
The Role of CXC Chemokines in Atherosclerosis, Cardiology Grand Rounds University of Minnesota Medical Center, Minneapolis, MN. December 1999
Angiotensin II Receptor Blockade Antagonizes the Proliferative Effects of Oxidized LDL,
World Congress on Heart Failure, Vancouver, B.C., Canada. July 2000
Angiogenic Chemokines in Atherosclerosis, Cardiology Grand Rounds University of Washington Medical Center, Seattle, WA. July 2000
New Thoughts on Atherosclerosis: CXC Chemokines and the“Inflammatory Hypothesis,”
Cardiology Grand Rounds Robert Wood Johnson Medical Center, New Brunswick, NJ. December 2000
Angiogenic Molecules in Cardiovascular Disease: the Role of CXC Chemokines,
Cardiology Grand Rounds University of Chicago Medical Center, Chicago, IL. January 2001
Lessons from Sharks:The Role of CXC Chemokines in Atherosclerosis, Cardiology Grand Rounds New York Hospital, New York, NY. February 2001
Heart Failure Therapy in the Managed Care Environment, Educational Session, American College of Cardiology, Orlando, FL March 2001
Management in the Patient with Heart Failure. Internal Medicine Grand Rounds Cedars Sinai Medical Center, Los Angeles, CA. June 2005
Update on Therapies in the Management of Heart Failure, Department of Medicine Grand Rounds, Cedars-Sinai Medical Center, Los Angeles, CA. February 2006
Use of Autologous Angiogenic Precursor Cells in the Treatment of Patients with Ischemic Cardiomyopathy. Controversies and Advances in the Treatment of Cardiovascular Diseaser, Los Angeles, CA. September 2010
Mechanism of Vulnerable Plaque: Lessons from Biomarkers and Imaging. Cardiovascular Disease Prevention: Novel Strategies and Emerging Therapies, Mayo Clinic College of Medicine, Cancun, Mexico. February 2014.
Coronary Artery Disease Prevention for the Primary Physician, Department of Medicine Grand Rounds, Glendale Memorial Hospital, Glendale, California. March 2014
Immune Response Biomarkers Characterize Endothelial Injury and Predict Acute Coronary Syndrome, Atherosclerosis Thrombosis Vascular Biology meetings, Minneapolis, MN. April 2014
Novel Biomarker Algorithmic Panel Measuring Permutations of Immune Response to Cardiac Endothelial Injury and Global Risk Factors Identifies Patients at Risk of Acute Coronary Syndrome, European Society of Cardiology meetings, Paris, FR. September 2019
Carotid Plaque Lipid Content is Reduced After 6 Months of Proprotein Convertase Subtilisin Kexin Type 9 Inhibition With Alirocumab: an Interim Analysis of a Serial Magnetic Resonance Imaging Study. Scientific Sessions, American Heart Association, Philadelphia. November, 2019
Bibliography/Publications: Research Papers (Peer Reviewed)
Massie BM, Simonini A, Minotti JR, Sahgal P, Wells L, Dudley GA: Specific Myopathy of Skeletal Muscle in Congestive Heart Failure. J. Am. Coll. Cardiology. 1996; Jan 27(1): 140-5.
Simonini A, Massie BM, Long CS, Qi M, Samarel AM: Alterations in Skeletal Muscle Gene Expression in the Rat with Chronic Congestive Heart Failure. J. Mol. and Cell. Cardiol. 1996; 28(8): 1683-91.
Simonini A, Long CS, McElhinny J, Yu P, Dudley GA, Massie BM: Heart Failure in Rats Causes Changes in Skeletal Muscle Which Are Not Explained by Reduced Activity. Circ. Research.1996; 79:128-136.
Simonini A, Chang K, Yue P, Long CS, Massie BM:Expression of Skeletal Muscle Sarcoplasmic Reticulum Ca2+-ATPase Is Reduced in Heart Failure. Heart 1999; 81:303-307
Simonini A , Moscucci M, Muller DWM, Pagani FD, Burdick MD, Strieter RM: IL-8 Is a Major Angiogenic Factor in Human Atherectomy Tissue . Circulation 2000; 101:1519-1526
Research Papers (Peer Reviewed) Submitted:
Simonini A, Dudley GA, Long CS, Xu Y, Prior B, Massie BM: Heart Failure in Rats Attenuates the Increase of Skeletal Muscle Oxidative Enzymes Induced by Mechanical Loading. J. Appl. Physiol.
Simonini A, Wang HM, Czer LSC, Trento A, Blanche, C, Burdick MD, Strieter RM: Expression of ELR-CXC Chemokines Are Associated with Allograft Atherosclerosis After Human Cardiac Transplantation and in the Rat Model. J. of Cardiac Failure
Simonini A, Pitt BS, Aviram M, Burdick MS, Strieter RM: Angiotensin II Receptor Blockade Attenuates the Proliferative Effects of Oxidized LDL on Coronary Smooth Muscle Cells Via Inhibition of Angiogenic Chemokines. Circ. Research
Simonini A, Luthringer D, Strieter RM: Inflammatory Angiogenic Chemokines
Are Associated with iNOS Expression in Failing Human Hearts. J. Am. Coll. Cardiology
Abstracts:
Simonini A, Schwartz DE, Carlisle AS: Adenosine in the Critically Ill Patient.
Chest Medicine. October, 1992
Samarel AM, Minotti JR, Simonini A: Skeletal Muscle Protein Synthesis in Congestive Heart
Failure. Circulation. November, 1993
Simonini A, Chang K, Yue P, Long CS, Massie BM: Expression of Skeletal Muscle Sarcoplasmic Reticulum Ca2+-ATPase Is Reduced in Heart Failure. Circulation. November, 1995
Massie BM, Simonini A, Minotti JR, Sahgal P, Wells L, Dudley GA: Specific Myopathy of Skeletal Muscle in Congestive Heart Failure. Circulation. November, 1995
Simonini A, Long CS, McElhinny J, Yu P, Dudley GA, Massie BM: Heart Failure in Rats Causes Changes in Skeletal Muscle Which Are Not Explained by Reduced Activity. Circulation. November, 1995
Simonini A, Muller DWM, Moscucci M, Pagani FD, Strieter RM:Macrophage-Derived Angiogenic Factor IL-8, CXC, and CC Chemokines Are Expressed in Acute Coronary Syndromes. Circulation. November, 1996
Simonini A, Dudley GA, Long CS, Xu Y, Prior B, Massie BM: Heart Failure in Rats Attenuates the Increase of Skeletal Muscle Oxidative Enzymes Induced by Mechanical Loading. Circulation. November, 1996
Simonini A, Moscucci M, Bates ER, Burdick MD, Strieter RM: Expression of CXC Chemokine IL-8 Is Associated with Smooth Muscle Cell Proliferation in Human Coronary In-Stent Restenosis. Circulation. November, 1997
Simonini A, Moscucci M, Muller DWM, Pagani FD, Burdick MD, Strieter RM: IL-8 Is a Major Angiogenic Factor in Human Atherectomy Tissue . Circulation. November, 1997
Simonini A, Bossone E, Aaronson KD, Armstrong WF: Doppler Indices of Diastolic Function Predict Peak Exercise Oxygen Consumption in Heart Failure. J. Am. Coll. Cardiology. March, 1998
Simonini A, Wang HM, Czer LSC, Trento A, Blanche, C, Burdick MD, Strieter RM: Expression of ELR-CXC Chemokines Are Associated with Allograft Atherosclerosis After Human Cardiac Transplantation and in the Rat Model. Circulation. November 1998
Simonini A, Pitt BS, Aviram M, Burdick MS, Strieter RM: Angiotensin II Receptor Blockade Antagonizes the Proliferative Effects of Oxidized LDL on Coronary Smooth Muscle Cells Via Inhibition of Angiogenic Chemokines. J. Am. Coll. Cardiology. March, 1999
Harrington DS, Zhao Y, Simonini A, Wong ND: Novel Biomarker Algorithmic Panel Measuring Permutations Of Immune Response To Cardiac Endothelia Injury And Global Risk Factors Identifies Patients At Risk For Acute Coronary Syndrome. J. Am Coll. Cardiology. March 2017
Simonini A, Harrington DS, Shiu V, Wong ND : Immune Response Biomarkers Characterize Endothelial Injury and Predict Acute Coronary Syndrome. ATVB Journal. May, 2017
Harrington DS, Zhao Y, Simonini A, Wong N: Novel Biomarker Algorithmic Panel Measuring Permutations of Immune Response to Cardiac Endothelial Injury and Global Risk Factors Identifies Patients at Risk of Acute Coronary Syndrome. European Heart Journal. October 2019
Sun J, Lepor NE, Canton G, Contreras L, Hippe DS, Isquith D, Balu N, Kedan I, Simonini A, Yuan C, Zhao XQ, Hatsukami TS: Carotid Plaque Lipid Content is Reduced After 6 Months of Proprotein Convertase Subtilisin Kexin Type 9 Inhibition With Alirocumab: an Interim Analysis of a Serial Magnetic Resonance Imaging Study. Circulation. November 2019